| 2024-01 |
Affinity‐Directed Site‐Specific Protein Labeling and Its Application to Antibody‐Drug Conjugates |
Advanced Science
|
| 2023-11 |
Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase |
Cell Chemical Biology
|
| 2023-11 |
Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors |
European Journal of Medicinal Chemistry
|
| 2023-11 |
Synthesis and antibacterial activities of baulamycin A inspired derivatives |
European Journal of Medicinal Chemistry
|
| 2023-01 |
Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib Resistance |
Cancers
|
| 2022-05 |
AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis |
Cell Death and Disease
|
| 2022-04 |
Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails |
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
|
| 2022-04 |
Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance |
JOURNAL OF MEDICINAL CHEMISTRY
|
| 2022-02 |
Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance |
MOLECULAR CANCER THERAPEUTICS
|
| 2022-01 |
Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1 |
Journal of Medicinal Chemistry
|
| 2022-01 |
Anti-cancer effects of 3, 4-dihydropyrimido[4,5- d ]pyrimidin- 2(1 H )-one derivatives on hepatocellular carcinoma harboring FGFR4 activation |
NEOPLASIA
|
| 2021-12 |
Novel Small Molecules Capable of Blocking mtRAS-Signaling Pathway |
FRONTIERS IN ONCOLOGY
|
| 2021-11 |
Anti-tumor activity of AZD4547 against NTRK1 fusion positive cancer cells through inhibition of NTRKs |
FRONTIERS IN ONCOLOGY
|
| 2021-09 |
Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9 |
Current Research in Chemical Biology
|
| 2021-08 |
Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3 |
JOURNAL OF MEDICINAL CHEMISTRY
|
| 2021-04 |
Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance |
International Journal of Molecular Sciences
|
| 2021-02 |
Natural and Synthetic Lactones Possessing Antitumor Activities |
International Journal of Molecular Sciences
|
| 2020-12 |
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development |
CELL
|
| 2020-12 |
Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2020-11 |
The first small molecules capable of strongly suppressing proliferation of cancer cells harboring BRAF class I/II/III mutations |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
| 2020-06 |
Discovery of a selective inhibitor of doublecortin like kinase 1 |
NATURE CHEMICAL BIOLOGY
|
| 2020-05 |
Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells |
JOURNAL OF CELLULAR PHYSIOLOGY
|
| 2020-03 |
Two-photon probes for the endoplasmic reticulum: its detection in a live tissue by two-photon microscopy |
CHEMICAL COMMUNICATIONS
|
| 2019-08 |
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14 |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2019-06 |
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as potent ALK-L1196M inhibitors |
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
|
| 2019-06 |
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity |
Cell Chemical Biology
|
| 2019-06 |
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome |
Cell Chemical Biology
|
| 2019-06 |
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype |
Cell Chemical Biology
|
| 2019-05 |
Raman-Based in Situ Monitoring of Changes in Molecular Signatures during Mitochondrially Mediated Apoptosis |
ACS Omega
|
| 2019-05 |
A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain |
FRONTIERS IN PHARMACOLOGY
|
| 2019-01 |
Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system |
BIOSCIENCE REPORTS
|
| 2018-12 |
Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2017-02 |
Highly stereoselective synthesis of mupirocin H |
TETRAHEDRON
|
| 2015-08 |
Development of small molecules targeting the pseudokinase Her3 |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2015-07 |
Non-receptor tyrosine kinase inhibitors enhances beta-cell survival by suppressing the PKC delta signal transduction pathway in streptozotocin - induced beta-cell apoptosis |
CELLULAR SIGNALLING
|
| 2015-04 |
In vitro metabolism of an estrogen-related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s |
BIOPHARMACEUTICS & DRUG DISPOSITION
|
| 2012-07 |
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2 |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2012-05 |
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2012-02 |
Rhodium-catalyzed reductive cyclization of 1,6-enynes and stereoselective synthesis of the putative structure of lucentamycin A and its stereoisomers |
TETRAHEDRON
|
| 2011-08 |
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2011-07 |
Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2011-05 |
Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors |
ACS MEDICINAL CHEMISTRY LETTERS
|
| 2011-04 |
Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line |
Bulletin of the Korean Chemical Society
|
| 2011-03 |
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1 |
ACS MEDICINAL CHEMISTRY LETTERS
|
| 2011-03 |
Synthesis of 1H-Pyrazole-1-carboxamide Derivatives and Their Antiproliferative Activity against Melanoma Cell Line |
ARCHIV DER PHARMAZIE
|
| 2011-03 |
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2010-10 |
Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer |
Journal Of Medicinal Chemistry
|
| 2010-10 |
Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line |
Bioorganic & Medicinal Chemistry Letters
|
| 2010-06 |
1,4-Dihydropyrazolo[4,3-d]imidazole phenyl derivatives: A novel type II Raf kinase inhibitors |
Bioorganic & Medicinal Chemistry Letters
|
| 2010-05 |
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFR alpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants |
BLOOD
|