| 2023-11 |
A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation |
Immunology Letters
|
| 2023-11 |
Novel small molecule-mediated restoration of the surface expression and anion exchange activity of mutated pendrin causing Pendred syndrome and DFNB4 |
Biomedicine & Pharmacotherapy
|
| 2023-09 |
Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy |
Theranostics
|
| 2023-07 |
Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non-Small Cell Lung Cancer |
Cancer Research and Treatment
|
| 2023-01 |
Structural optimization of novel Ras modulator for treatment of Colorectal cancer by promoting β-catenin and Ras degradation |
Bioorganic Chemistry
|
| 2022-12 |
Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling |
Pharmaceutics
|
| 2022-12 |
Selective cytotoxicity of a novel mitochondrial complex I inhibitor, YK-135, against EMT-subtype gastric cancer cell lines due to impaired glycolytic capacity |
BMB Reports
|
| 2022-11 |
Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus |
BMB reports
|
| 2022-10 |
Euodia daniellii Hemsl. Extract and Its Active Component Hesperidin Accelerate Cutaneous Wound Healing via Activation of Wnt/beta-Catenin Signaling Pathway |
Molecules
|
| 2022-09 |
Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer |
Experimental and Molecular Medicine
|
| 2022-04 |
Indirubin-3′-alkoxime derivatives for upregulation of Wnt signaling through dual inhibition of GSK-3β and the CXXC5-Dvl interaction |
BIOORGANIC CHEMISTRY
|
| 2022-02 |
Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2 |
Cells
|
| 2021-12 |
Development of a DABCO-Succinic Acid Based Catalytic System for the Aza-Michael Addition and Aza-Michael/Knoevenagel Tandem Reaction of Thiazolidine-2,4-dione to Electron Deficient Alkenes |
JOURNAL OF ORGANIC CHEMISTRY
|
| 2021-09 |
Novel positive allosteric modulator of protease-activated receptor 1 promotes skin wound healing in hairless mice |
BRITISH JOURNAL OF PHARMACOLOGY
|
| 2021-08 |
Suppressing Pyroptosis Augments Post-Transplant Survival of Stem Cells and Cardiac Function Following Ischemic Injury |
International Journal of Molecular Sciences
|
| 2021-07 |
Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction |
BIOORGANIC CHEMISTRY
|
| 2021-04 |
Suppression of Wnt/β-catenin and RAS/ERK pathways provides a therapeutic strategy for gemcitabine-resistant pancreatic cancer |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
| 2021-02 |
Randomized, Controlled Trial to Evaluate the Effect of Dapagliflozin on Left Ventricular Diastolic Function in Patients With Type 2 Diabetes Mellitus: The IDDIA Trial. |
CIRCULATION
|
| 2020-12 |
Investigation of memory-enhancing botanical mixture and their isolated compounds for inhibition of amyloid-β and tau aggregation |
Applied Biological Chemistry
|
| 2020-08 |
PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation |
COMMUNICATIONS BIOLOGY
|
| 2020-08 |
Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury |
THERANOSTICS
|
| 2020-08 |
Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: Discovery of novel potent ANO1 inhibitors |
BIOORGANIC CHEMISTRY
|
| 2020-07 |
Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers |
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
|
| 2020-04 |
Identification and validation of VEGFR2 kinase as a target of voacangine by a systematic combination of DARTS and MSI |
Biomolecules
|
| 2019-11 |
Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma |
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
|
| 2019-08 |
FusionPro, a Versatile Proteogenomic Tool for Identification of Novel Fusion Transcripts and Their Potential Translation Products in Cancer Cells |
MOLECULAR & CELLULAR PROTEOMICS
|
| 2019-05 |
Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer |
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
|
| 2019-05 |
Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration |
JOURNAL OF CLINICAL INVESTIGATION
|
| 2019-04 |
CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth |
Life Science Alliance
|
| 2019-03 |
Simultaneous Suppression of Multiple Programmed Cell Death Pathways by miRNA-105 in Cardiac Ischemic Injury |
Molecular Therapy - Nucleic Acids
|
| 2019-03 |
RNA‐dependent chaperone (chaperna) as an engineered pro‐region for the folding of recombinant microbial transglutaminase |
BIOTECHNOLOGY AND BIOENGINEERING
|
| 2019-01 |
Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson's Disease Therapy |
Journal of Medicinal Chemistry
|
| 2019-01 |
A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer |
SCIENTIFIC REPORTS
|
| 2018-11 |
A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab |
EXPERIMENTAL AND MOLECULAR MEDICINE
|
| 2018-11 |
β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β |
EMBO REPORTS
|
| 2018-06 |
Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
|
| 2018-04 |
Glycosylation of Hemagglutinin and Neuraminidase of Influenza A Virus as Signature for Ecological Spillover and Adaptation among Influenza Reservoirs |
VIRUSES-BASEL
|
| 2018-01 |
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2017-09 |
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction |
NATURE COMMUNICATIONS
|
| 2017-04 |
HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis |
CANCER LETTERS
|
| 2017-02 |
Synthetic strategy for increasing solubility of potential FLT3 inhibitor thieno[2,3-d]pyrimidine derivatives through structural modifications at the C<inf>2</inf> and C<inf>6</inf> positions |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2017-01 |
Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2016-11 |
KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer. |
ONCOTARGET
|
| 2016-10 |
Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2016-09 |
Structural modifications at the 6-position of thieno[2,3- d ]pyrimidines and their effects on potency at FLT3 for treatment of acute myeloid leukemia |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2016-06 |
Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation. |
NATURE CHEMICAL BIOLOGY
|
| 2015-10 |
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2015-09 |
Identification of a thienopyrimidine derivatives target by a kinome and chemical biology approach |
ARCHIVES OF PHARMACAL RESEARCH
|
| 2015-04 |
2-(Trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34(+) haematopoietic stem cells |
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
|
| 2015-04 |
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization |
JOURNAL OF MEDICINAL CHEMISTRY
|
| 2014-10 |
Secondary structure of the Irf7 5’-UTR, analyzed using SHAPE (selective 2’-hydroxyl acylation analyzed by primer extension) |
BMB REPORTS
|
| 2014-10 |
Development of a Novel Class of Mitochondrial Ubiquinol-Cytochrome c Reductase Binding Protein (UQCRB) Modulators as Promising Antiangiogenic Leads |
JOURNAL OF MEDICINAL CHEMISTRY
|
| 2014-10 |
Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2014-08 |
The small molecule indirubin-3'-oxime activates Wnt/b-catenin signaling and inhibits adipocyte differentiation and obesity |
INTERNATIONAL JOURNAL OF OBESITY
|
| 2014-07 |
Chemopreventive and chemotherapeutic effect of a novel histone deacetylase inhibitor, by specificity protein 1 in MDA-MB-231 human breast cancer cells |
EUROPEAN JOURNAL OF CANCER PREVENTION
|
| 2014-06 |
Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKK beta inhibitors |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2014-05 |
P300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis |
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
|
| 2014-03 |
Lactam-based HDAC inhibitors for anticancer chemotherapy: Restoration of RUNX3 by posttranslational modification and epigenetic control |
CHEMMEDCHEM
|
| 2014-01 |
NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription |
APOPTOSIS
|
| 2014-01 |
Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction |
NATURE CHEMICAL BIOLOGY
|
| 2013-12 |
A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling |
CANCER CHEMOTHERAPY AND PHARMACOLOGY
|
| 2013-11 |
New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2013-07 |
Identification of methyl violet 2B as a novel blocker of focal adhesion kinase signaling pathway in cancer cells |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
| 2013-07 |
A248, a novel synthetic HDAC inhibitor, induces apoptosis through the inhibition of specificity protein 1 and its downstream proteins in human prostate cancer cells |
MOLECULAR MEDICINE REPORTS
|
| 2013-05 |
Synthesis and biological evaluation of novel aliphatic amido-quaternaryammonium salts for anticancer chemotherapy: Part II |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2013-02 |
Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2013-02 |
Discovery of Pyridone-Based Histone Deacetylase Inhibitors: Approaches for Metabolic Stability |
CHEMMEDCHEM
|
| 2012-12 |
Property-Based Optimization of Hydroxamate-Based gamma-Lactam HDAC Inhibitors to Improve Their Metabolic Stability and Pharmacokinetic Profiles |
JOURNAL OF MEDICINAL CHEMISTRY
|
| 2012-06 |
Structure and property based design, synthesis and biological evaluation of gamma-lactam based HDAC inhibitors: Part II |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2012-06 |
Structure-Activity Relationship of Novel Lactam Based Histone Deacetylase Inhibitors as Potential Anticancer Drugs |
Bulletin of the Korean Chemical Society
|
| 2012-01 |
Gene expression profiling of KBH-A42, a novel histone deacetylase inhibitor, in human leukemia and bladder cancer cell lines |
ONCOLOGY LETTERS
|
| 2011-07 |
Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2011-03 |
Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618 |
CARCINOGENESIS
|
| 2011-02 |
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2011-02 |
Identification of a novel small molecule targeting UQCRB of mitochondrial complex III and its anti-angiogenic activity |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
| 2010-12 |
Structure based optimization of chromen-based TNF-α converting enzyme (TACE) inhibitors on S1′ pocket and their quantitative structure-activity relationship (QSAR) study |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2010-11 |
Prediction of relative stability between TACE/gelastatin and TACE/gelastatin hydroxamate |
Bulletin of the Korean Chemical Society
|
| 2010-11 |
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2010-10 |
Property based optimization of δ-lactam HDAC inhibitors for metabolic stability |
Bioorganic & Medicinal Chemistry Letters
|
| 2010-10 |
Regulation of in vitro A beta(1-40) Aggregation Mediated by Small Molecules |
JOURNAL OF ALZHEIMERS DISEASE
|
| 2010-03 |
KBH-A42, a histone deacetylase inhibitor, inhibits the growth of doxorubicin-resistant leukemia cells expressing P-glycoprotein |
Oncology Reports
|
| 2009-12 |
RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells |
INTERNATIONAL JOURNAL OF CANCER
|
| 2009-10 |
A Novel gamma-Lactam-Based Histone Deacetylase Inhibitor Potently Inhibits the Growth of Human Breast and Renal Cancer Cells |
Biological & Pharmaceutical Bulletin
|
| 2009-01 |
A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells |
Biochemical Pharmacology
|
| 2009-01 |
Reversine Increases the Plasticity of Lineage-committed Cells toward Neuroectodermal Lineage |
Journal of Biological Chemistry
|
| 2008-07 |
Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus |
Phytotherapy Research
|
| 2008-07 |
Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model |
Experimental And Molecular Medicine
|
| 2008-03 |
In vitro metabolism of KBH-A40, a novel δ-lactam-based histone deacetylase (HDAC) inhibitor, in human liver microsomes and serum |
Xenobiotica
|
| 2008-01 |
Chromen-based TNF-α converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2008-01 |
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|