Ever since the great success of gleevec in cancer biology, tremendous efforts have made to identify new effective cancer targets. However, the targets that delivered FDA-approved drugs are limited and extremely biased in the mediators of signal pathways such as kinases etc. However, in many times, those targets show slim efficacy with rapid occurrence of resistance. For this reason, it is necessary to explore the targets that can tolerate heterogeneity of cancers with sufficient efficacy. Although the targets in cancer-specific metabolism are emerging as alternative targets, they mainly focus on energy metabolism involving glucose or fatty acids. We are addressing potentials of amino acid metabolism or amino acid signaling as cancer targets. Work is in progress in the following areas.
•Investigating the role of amino acids on cellular physiologies such as cell growth and death, autophagy, and circadian rhythm.
•Investigating the mechanism of amino acid signaling
•Identification of intracellular amino acid sensors
•Investigating the molecular network between translation, metabolism, and cancer